Selected Biosensors for Neurotoxicity Testing

Tissue Morphology and Cell Impedance Based Biosensors for Toxicity Testing

In vitro neurotoxicity testing and toxicity effect quantification plays an important role in many disciplines of biomedicine as an alternative to in vivo methods. The principle of the majority of in vitro methods corresponds to the basic concept of biosensors, i.e. measured quantity is by means of biological sensing element transformed to physical quantity easily measurable by electrical method...

Poster: alternative testing methods for toxicity to reproduction

The development of the nervous system is a rather complex process known to be affected by different drugs and chemicals. Therefore, regulatory test guidelines have been adopted for the prediction and assessment of developmental neurotoxicity (U.S.EPA OPPTS 870.6300 and OECD TG 426). However, current in vivo test methods are laborious, costly and necessitate use of considerably high numbers of l...

Rapid detection of neurotoxic insecticides in food using disposable acetylcholinesterase-biosensors

Preparation and performance of a colorimetric biosensor using acetylcholinesterase and indoxylacetate for assay of nerve agents and drugs

Different toxic compounds can target the cholinergic nervous system. Acetylcholinesterase (AChE; EC 3.1.1.7) is one of the most crucial components of the cholinergic nervous system and thus many of the toxins interact with this enzyme. As to inhibitors, nerve agents used as chemical warfare, some insecticides, and drugs influencing the cholinergic system are common examples of AChE inhibitors. ...

Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing.

The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to "frontline...